KetoChix Lift Up Heavy Things and Put Them Down Again

brainweights

A recent study from the University of Sydney suggests that resistance training has a direct impact on age-related cognitive decline. As I’ve said elsewhere you can’t talk about the body without talking about the brain. When you talk about the brain you imply a conversation about the body; when you talk about the body you imply a conversation about the brain.

Further, we have developed simple testing measures for mitochondrial function that involve an improvement in V02 max–and while you can achieve v02 max improvement nutritionally, the most expedient way to do it is through exercise.

Interesting to note in this study—they used what they call “sham” measures–creating fake cognitive testing and fake exercise routines so the subjects wouldn’t know what exactly was being tested. Seated calisthenic and mildly aerobic measures did not work. It was specifically resistance training that improved all measures of cognitive function tested in the study.

KetoChix are Brainy Chix. We Lift Heavy Things and Put Them Down Again.

Ketones and the Blood-Brain Barrier

Barrière hématoencéphalique

Often people will ask me where we get our definition of keto-adaptation as being consistent blood glucose below 85 and morning ketones between.5 and 3. It’s an obvious logical step in understanding how the body adapts. Ketones and glucose compete for fuel. You can’t get into a zero glucose state–there are brain cells, for example, that can only operate on glucose, although the amount of glucose the brain needs is minimal and doesn’t need to come from dietary sources. The brain can use multiple substrates (fuel sources) and becomes more efficient when it does so. The brain that operates only on glucose is an inefficient brain. The problem is the Standard American Diet trains brains to run on glucose only–so much so that it becomes glucose dependent and its use of other available substrates becomes minimal. This leads to premature aging, neurodegenerative disease, and flat out grey matter shrinkage.  It also provides epigenetic therapy reducing the expression and/or effect of genes that lead one toward cancer, CVD, and auto-immune disorders.

You can see why we don’t give a shit about your skinny jeans. It’s usually a nice secondary effect. But it isn’t our goal.

The goal is to get our glucose dependent brains to be operating on multiple other substrates, which it really is designed to do. Astrocytes, for example, make their own ketones in the brain, it wants to be using ketones, even if we’ve beaten it into submission with years of glucose flooding. All we need to do is provide the brain with enough ketones (and pryuvate and lactate–but that’s another post) to let it begin to operate optimally.

But how do we do that?  Well, people started testing ketones. If I’m making ketones then I must be using them, right? Well. Hold on there. We know that high amounts of circulating ketones and even pure fatty acids can reach the mitochondria of the muscle tissue through capillaries providing an energy source.

It’s only in considering just HOW the ketones reach the brain that the circulating blood glucose becomes not just relevant to keto-adaptation but crucial to it.

The brain is surrounded by something called the BBB–the blood brain barrier. The BBB has selective permeability that varies in different metabolic states. Those who have hung around KetoChix a bit understand that everything in biochemistry works in ratios (that’s why we figure out our food macros not in absolute calories but in ratios of fat:protein + carb) and substrates in the body have the tendency to act like a clutch and gas pedal. In this case you can think of glucose as clutch and ketones as the gas. Because the ketones can only GET to the brain if the circulating plasma glucose is low. It works in an inversely proportional ratio.

The important thing to remember is that glucose and ketones have the gas and clutch relationship.  What people started doing when measuring ketones was to verify that you are eating sufficient fat and keeping carbs low enough that you are actually making them. That’s only the first step. The idea is that you are using them, preferentially. The lower your blood glucose, the more your tissues—all of your tissues not just brain tissue–are using ketones as their PREFERRED fuel. Since large population studies correlate disease states with fasting blood glucose of over 85, we can guess where that gas and clutch rhythm reaches its maximal efficiency.

Some more studies to read if you want background and like to connect dots:

http://www.ncbi.nlm.nih.gov/pubmed/7611392
http://www.ncbi.nlm.nih.gov/pubmed/3884391

The Nervous System and Metabolic Dysregulation: Emerging Evidence Converges on Ketogenic Therapy

atp

One might well ask: why are we so fascinated with nutritional therapies that work on things like multiple sclerosis and epilepsy when what most people are worried about are obesity and its co-morbid disorders? Well, obesity is a metabolic disorder and metabolic dysfunction and neuronal dysfunction go hand in hand. They co-exist. Which causes the other is a subject of debate (and perhaps philosophy), however, when we talk about one we are always implying a conversation about the other. When we talk about blood glucose and the brain for example, we are also talking about blood glucose and all of the cells.

I’d also like to explain that what we are talking about doing here is inducing what may be to some “hypoglycemia.” But “hypoglycemia” presumes a glucose dependent cellular system. So what is hypoglycemic in a “sugar-burner” is not in one in continuous ketosis. The negatives traditionally associated with hypoglycemia come from hypoglycemia in cells that are only making ATP (the cell’s “fuel”) with glucose. (I am NOT talking about people on insulin or insulin secretagogues. The bar on hypoglycemia is much higher in people on these classes of diabetes drugs.)

Glucose is used in cells to make ATP, but the cell can also use ketone bodies–and when there is adequate ATP being produced in the cells through ketones, the hypoglycemic extracellular environment actually provides positive effects including reduced inflammation, heightened mood, reduced pain, and higher level cognition, as seen in this study highlighted below.

All of these things are therapeutic for and preventative of multiple disease processes so a higher functioning brain and nervous system implies better functioning cells all over the body, and vice versa. We can’t talk about your health without involving the brain. And you can’t talk about the brain without talking about the over all health of the body. We usually talk about the mind-body connection in psychological terms exclusively, but it’s really a misunderstanding. The mind is the body and the body is the mind.

via The Nervous System and Metabolic Dysregulation: Emerging Evidence Converges on Ketogenic Diet Therapy.

Vegetables, Nutrients, and Supplements

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This was a recent talk given by our hero Dr. Wahls in Calgary.

Tagging off my recent post on why we oppose Zero Carb–at about 21:00 Dr. Wahls talks about Dr. Bowman’s research, which inspired her to track, test, and target 31 different micronutrients in her quest to  provide optimal mitochondrial nutrition.

Dr. Bowman’s research was very similar to Dr. Perlmutter’s in that he tracked nutrient levels and the size of the brain. The size of your brain isn’t always apparent (although it may show up in bizarre behavioral and attitudinal eccentricities and poor cognitive performance) but it can be correlated to your nutritional status in significant ways.

Dr. Wahls emphasis on low glycemic vegetables is because of the importance of these nutrients. In order for your ketogenic diet to be optimal you must include these vegetables in your diet. Crucifers and sulfur, leafy greens, and richly colored vegetables and berries. You also should be eating wild caught fish and organ meats and focusing on grass fed meats in order to get the right amount of nutrients.

However, some things may come up in an attempt to fulfill this diet. Some people have food sensitivities, allergies, gastro-intestinal issues, or insulin resistance that makes some vegetables difficult. They will either cause allergy or disease flares, intestinal issues, and higher blood glucose. (For example I am limited at the moment to some sulfur in the form of mushrooms, onions, and garlic, 1-2 cups of leafy greens–if that–and avocados or else I may have serious gastrointestinal distress, disease activity, and higher blood glucose.) The goal is to repair and heal the body so eventually the body can tolerate these nutritionally dense foods and it does happen. As you blood glucose becomes more stable you become less reactive.

But here’s a reason NOT to cut those foods out: the scale moves quicker if you do. Ill-informed and not a good choice.

So what about in the meantime?  If you are among the gastro-intestinal/allergy/autoimmune/insulin resistant patients who have sensitivity to these vegetables?

You might at this time consider supplementation.

Here is what I am doing currently–we do not necessarily have a formal recommendation for supplementation at this time, but I am experimenting on myself and using my own blood work to find the happy medium for me.  You should consult with your doctor on your own recommendations as mine may not be the same as yours. For example, I have chronically low vitamin D, low CO2, chronically high WBC, and MTHFR so my levels are set to that. Particularly the vitamin D supplementation should be worked out with your primary care provider:

-a vegetable and fruit extract multivitamin (an insurance policy against all the nutrient dense vegetables and fruits I am not having).
-200 mg of CoEnzyme Q10
-5000 IU of Vitamin D3
-methyl B12 1000 mcg
-methyl folate 1000 mcg
-calcium citrate 250 mg
-algae capsules

Food is always the best source of any nutrient–supplementation is not entirely benign and it can also have its own unintended secondary effects so always approach supplementation with caution and discuss with your primary care provider.

via Dr. Terry Wahls Presentation – YouTube.

This Is Your Brain On Ketones

Your Brain on Ketones
Those Itty Bitty Dots In The Boxes On the Left…Those Are Those Things That Make You Feel So Good

So in an infant with Ohtahara syndrome being treated with the ketogenic diet, they were actually able to see ketones in the brain using proton magnetic resonance spectroscopy.

I was actually fully expecting to see this:

Nyan Cat

via Brain ketones detected by proton magnetic resonance spectroscopy in an infant with Ohtahara syndrome treated with ketogenic diet – Springer.

It’s All About the Blood Glucose

A1c-Graph

Why am I obsessed with blood glucose?

I am obsessed with blood glucose because there is no better easily observed predictor of overall health, longevity, and well-being.  

My husband has been passionate about low carb nutrition for diabetics and for over all good health since the early 90s. At this time, the medical community was still in the throes of the low fat hypothesis. People thought my husband was something of a nut–and I can remember heated fights at dinner parties where other physicians accused my husband of medical malpractice for encouraging low carb diets.  Things have started to turn around.

Blood Sugar High!

You’ll notice the call to sanity implicit to the article linked above. People might ask, if low carb treatment of diabetics is so glaringly superior to any pharmaceutical or nutritional approach available, why does it still not reach the level of mainstream? Because the burden of evidence placed upon it is almost impossible to achieve. Meanwhile, clinicians such as the ones listed as the authors of the above study, continue to use it with success. Their patients lives are more important. You can’t argue with the results once you put it into practice. Especially those of us who have to put it into practice ourselves.

After we were married in 2000, while we were living in Manhattan, he would take the train to Dr. Richard Bernstein’s office and Dr. Bernstein kindly let my husband shadow him. Dr. Bernstein is one of the doctors listed in the article above and he is the pioneer patron saint of low carb nutrition. His first big splash was when he revolutionized diabetes management in the 70s as the inventor of continuous blood glucose monitoring. Billions have been made on this radical idea in diabetes management as the test strips and the glucometers still fly off the shelves. But they left the accompanying nutritional philosophy in the dust.

Despite being ridiculed and mocked, Dr. Bernstein continued with low carb management of diabetes. Not just his patients. Dr. Bernstein himself is a Type 1 who, prior to discovering he could control his own diabetes by reducing carbohydrates, was headed for an early death. This is what I call SKIN IN THE GAME, people. So many nutritional and health gurus are people who started off lean, fit, healthy, and beautiful. The ones I listen to are ones with SKIN IN THE GAME. These are the people who risk their own health on what they are preaching at high stakes. Fake tans and poseur sympathy with the obese and health challenged is not what I call skin.

My husband had read Dr. Bernstein’s book, Dr. Bernstein’s Diabetes Solution: The Complete Guide to Achieving Normal Blood Sugars
but seeing him in action was a different experience altogether. Bernstein’s results with diabetics–both Type 1 and Type 2–were hard to argue with. My husband began encouraging his patients to use Dr. Bernstein’s nutritional protocol to treat diabetes. He was convinced (and still is) that Type 2 diabetes is a curable disease, given the right nutritional approach.

It was challenging, however. People need a lot of training and a lot of support to change their entire point of view on diet and food. It is a new way of eating, a new way of thinking about their diabetes, and a new way of living. Most of you probably understand without much explanation, contemporary primary care medicine is not really set up for this kind of lifestyle change. Moreover, more frequently PCPs like my husband (who’s specialty is internal medicine) tend to see diabetes as an endocrinologist’s problem. My husband didn’t see it that way. Then, he saw his job as keeping you out of the hospital and getting you out quickly if you had to go in. He knew that this mission hinged on getting his patients the best control of their blood sugar they could get. And he knew that was all nutritional.

That’s why we started the nutrition clinic. I did the coaching and patient education and he saw them for in-office visits to check on their products through blood work and physical exam. The already good results he had in his practice became staggering. Patients went from 7 or 8 medications to 1 or 2, or even none. We sought many ways to find a way to better integrate the clinic into the existing group practice he had, but to no avail. We are still working on it.

For his board re-certification, we both worked together to collate a much larger data set to include his entire practice, not just the patients in the clinic. Data doesn’t lie: all complications associated with diabetes were directly correlated to HbA1c, and that the lab reference ranges were set too high. We saw complications starting at much lower threshold than what the reference ranges indicated. The lower the A1C, the less problems. Period.

This isn’t controversial, per se. Few in medicine would argue with this correlation. What may be contentious is our current standard, in line with Dr. Bernstein’s—an HbA1c below 5. What may be more contentious still is that we don’t consider diabetics a special case. In America we are essentially all diabetic because of the high carbohydrate, pro-inflammatory diet that has become standard. Therefore the reference ranges labs provide are drawn from population studies done on populations that are already on a path to multiple disease processes, neurodegeneration, and premature aging. The average ranges are above what you want to be shooting for.

This makes the doctor’s evaluation of your HbA1c at 5.2 as “normal” suspect. To us, you are already pre-diabetic.

It turns out that we are not alone in our point of view.

Dr. Perlmutter, author of Grain Brain: The Surprising Truth about Wheat, Carbs, and Sugar–Your Brain’s Silent Killers, recently posted a German study that correlated A1C and fasting glucose with lower memory and reduced hippocampal structure. In other words, the higher your A1C, the smaller your brain.


Shrinkage-of-Memory-Center-Blood-Sugar

What is the key to managing those sugars, according to Dr. Perlmutter? Not just low carb.  HIGH FAT.

This isn’t the only correlation. It isn’t a coincidence that the place at which there is negative shrinkage–that is to say GROWTH–is the same place that Dr. Seyfried, author of  Cancer as a Metabolic Disease: On the Origin, Management, and Prevention of Cancer finds tumors shrinking and cancer being de-fanged.

There are other places where our lower level numbers are justified. For one small example, in April of last year, Nature published an article that showed that hyperglycemia was associated with multiple kinds of cancer development. And “evidence is also provided that risk is already increased in the pre-diabetic and normal ranges for several cancers.”

If you haven’t already read it, my post on defining keto-adaptation with low blood sugar (and HbA1C), explains why I think that defining keto-adaptation without at least a measure of fasting blood glucose is meaningless.  The above provides further justification for the levels we set.

Have you bought your glucometer yet?